Tadalafil, a phosphodiesterase type 5 inhibitor, is the active ingredient in Vidalista 80 mg, a medicine mostly used to treat severe cases of erectile dysfunction in men. 30 to 60 minutes after swallowing the tablet, Vidalista 80 mg starts to work. A prolonged window for sexual activity is provided by the 36-hour duration of Vidalista 80 mg's effects. The time to commencement of effect may be much longer if taken with food or soon after a meal. Tadalafil's metabolism may be hampered for 72 hours before and after taking the medication if grapefruit juice and grapefruit are consumed.